Top-down dendritic input increases the gain of layer 5 pyramidal neurons.

@article{Larkum2004TopdownDI,
  title={Top-down dendritic input increases the gain of layer 5 pyramidal neurons.},
  author={Matthew Evan Larkum and Walter Senn and Hans-R L{\"u}scher},
  journal={Cerebral cortex},
  year={2004},
  volume={14 10},
  pages={1059-70}
}
The cerebral cortex is organized so that an important component of feedback input from higher to lower cortical areas arrives at the distal apical tufts of pyramidal neurons. Yet, distal inputs are predicted to have much less impact on firing than proximal inputs. Here we show that even weak asynchronous dendritic input to the distal tuft region can significantly increase the gain of layer 5 pyramidal neurons and thereby the output of columns in the primary somatosensory cortex of the rat… CONTINUE READING
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