Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

@article{Oyler2018TopDT,
  title={Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.},
  author={Benjamin L Oyler and Mohd M. Khan and Donald F Smith and Erin M Harberts and David P. A. Kilgour and Robert K Ernst and Alan S. Cross and David R. Goodlett},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2018},
  volume={29 6},
  pages={
          1221-1229
        }
}
Recent advances in lipopolysaccharide (LPS) biology have led to its use in drug discovery pipelines, including vaccine and vaccine adjuvant discovery. Desirable characteristics for LPS vaccine candidates include both the ability to produce a specific antibody titer in patients and a minimal host inflammatory response directed by the innate immune system. However, in-depth chemical characterization of most LPS extracts has not been performed; hence, biological activities of these extracts are… CONTINUE READING
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