Tooth germ invagination from cell-cell interaction: Working hypothesis on mechanical instability.

@article{TakigawaImamura2015ToothGI,
  title={Tooth germ invagination from cell-cell interaction: Working hypothesis on mechanical instability.},
  author={Hisako Takigawa-Imamura and Ritsuko Morita and Takafumi Iwaki and Takashi Tsuji and Kenichi Yoshikawa},
  journal={Journal of theoretical biology},
  year={2015},
  volume={382},
  pages={284-91}
}
In the early stage of tooth germ development, the bud of the dental epithelium is invaginated by the underlying mesenchyme, resulting in the formation of a cap-like folded shape. This bud-to-cap transition plays a critical role in determining the steric design of the tooth. The epithelial-mesenchymal interaction within a tooth germ is essential for mediating the bud-to-cap transition. Here, we present a theoretical model to describe the autonomous process of the morphological transition, in… CONTINUE READING
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