Tools for Detection of Schistosomiasis in Resource Limited Settings

@article{Ajibola2018ToolsFD,
  title={Tools for Detection of Schistosomiasis in Resource Limited Settings},
  author={O. Ajibola and B. H. Gulumbe and A. Eze and E. Obishakin},
  journal={Medical Sciences},
  year={2018},
  volume={6}
}
Schistosomiasis is a debilitating disease affecting over 200 million people, with the highest burden of morbidity and mortality in African countries. Despite its huge impact on the health and socio-economic burden of the society, it remains a neglected tropical disease, with limited attention from governments and stakeholders in healthcare. One of the critical areas that is hugely under-developed is the development of accurate diagnostics for both intestinal and urogenital schistosomiasis… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
Advances in the Diagnosis of Human Schistosomiasis
TLDR
Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis. Expand
New diagnostic tools in schistosomiasis.
TLDR
An update of the latest developments in schistosomiasis diagnosis, including microscopic techniques, rapid diagnostic tests for antigen detection, polymerase chain reaction (PCR) assays and proxy markers for morbidity assessments, is provided. Expand
Diagnostics for schistosomiasis in Africa and Arabia: a review of present options in control and future needs for elimination
TLDR
Current options for diagnosis of schistosomiasis at different levels are reviewed, highlighting several strengths and weaknesses therein and it is proposed that more cost-effective diagnostics and clinical staging algorithms are needed. Expand
Serological approaches for the diagnosis of schistosomiasis - A review.
TLDR
This narrative review describes and critically discusses the results of published studies on the evaluation of serological assays that detect antibodies against different Schistosoma species of humans, and sets the scene for serological diagnosis of schistosomiasis and the interpretation of results. Expand
Diagnosis and treatment of schistosomiasis in children in the era of intensified control
TLDR
A comprehensive overview about schistosomiasis including recent trends in the number of people treated with praziquantel and the latest developments in diagnosis and control is presented. Expand
The global status of schistosomiasis and its control.
TLDR
There is need for increased support for schistosomiasis control in the most severely affected countries, which are among the least developed whose health systems face difficulties to provide basic care at the primary health level. Expand
Detection of duo-schistosome infection from filtered urine samples from school children in Zambia after MDA
TLDR
The approach is an effective means of detecting low intensity infection, which will enhance the effectiveness of surveillance and assess the impact of MDA control programs against schistosomiasis. Expand
Questionnaires for rapid screening of schistosomiasis in sub-Saharan Africa.
TLDR
Questionnaires are now available for promptly defining the magnitude of schistosomiasis in a large area, which will allow limited resources for morbidity control to be allocated optimally, and although results are encouraging, the questionnaires need additional validation. Expand
Improving diagnosis of urogenital schistosome infection
  • F. Mutapi
  • Medicine
  • Expert review of anti-infective therapy
  • 2011
TLDR
The detection of parasite DNA in urine samples by PCR described in the article by Ibironke et al improves on this limitation and is compared with current methods and discusses its potential use in field settings. Expand
Cost analysis of tests for the detection of Schistosoma mansoni infection in children in western Kenya.
TLDR
A costing tool is provided to guide program managers in evaluating detection costs in specific settings, as costs may vary temporally and spatially. Expand
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