Tools and talk: an evolutionary perspective on the functional deficits associated with amyotrophic lateral sclerosis.

Abstract

We propose that amyotrophic lateral sclerosis (ALS), and frontotemporal dementia may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. We discuss how hand-arm function, locomotion, brainstem function (involving vocalization/speech, swallowing and breathing), and cognitive impairment share… (More)
DOI: 10.1002/mus.24132

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