Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.

@article{Maidorn2016ToolsAL,
  title={Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.},
  author={Manuel Maidorn and Silvio O Rizzoli and Felipe Opazo},
  journal={The Biochemical journal},
  year={2016},
  volume={473 20},
  pages={3385-3399}
}
The synapse is densely packed with proteins involved in various highly regulated processes. Synaptic protein copy numbers and their stoichiometric distribution have a drastic influence on neuronal integrity and function. Therefore, the molecular analysis of synapses is a key element to understand their architecture and function. The overall structure of the synapse has been revealed with an exquisite amount of details by electron microscopy. However, the molecular composition and the… CONTINUE READING
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