Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion.

@article{Ferris2014TooMO,
  title={Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion.},
  author={Robert L Ferris and Binfeng Lu and Lawrence P Kane},
  journal={Journal of immunology},
  year={2014},
  volume={193 4},
  pages={
          1525-30
        }
}
T cell exhaustion is thought to be a natural mechanism for limiting immune pathology, although it may be desirable to circumvent this mechanism to help eliminate viral reservoirs or tumors. Although there are no definitive markers, a fingerprint for exhausted T cells has been described that includes the transmembrane proteins PD-1, LAG3, and Tim-3. However, apart from the recruitment of tyrosine phosphatases to PD-1, little is known about the biochemical mechanisms by which these proteins… CONTINUE READING

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