Too much of a good thing: mechanisms of gene action in Down syndrome.

@article{Reeves2001TooMO,
  title={Too much of a good thing: mechanisms of gene action in Down syndrome.},
  author={Roger H Reeves and Laura L Baxter and Joan T. Richtsmeier},
  journal={Trends in genetics : TIG},
  year={2001},
  volume={17 2},
  pages={83-8}
}
The molecular mechanisms underlying the specific traits in individuals with Down syndrome (DS) have been postulated to derive either from nonspecific perturbation of balanced genetic programs, or from the simple, mendelian-like influence of a small subset of genes on chromosome 21. However, these models do not provide a comprehensive explanation for experimental or clinical observations of the effects of trisomy 21. DS is best viewed as a complex genetic disorder, where the specific phenotypic… CONTINUE READING
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