Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance.

  title={Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance.},
  author={Andrew D Hislop and Michael Kuo and Adrian B Drake-Lee and Arne N. Akbar and Wolfgang F. Bergler and Nicolas Hammerschmitt and Naeem Khan and Umaimainthan Palendira and Alison M. Leese and Judith M Timms and Andrew I Bell and Christopher D Buckley and Alan B. Rickinson},
  journal={The Journal of clinical investigation},
  volume={115 9},
Patients with infectious mononucleosis (IM) undergoing primary EBV infection show large expansions of EBV-specific CD8+ T cells in the blood. While latent infection of the B cell pool is quickly controlled, virus shedding from lytically infected cells in the oropharynx remains high for several months. We therefore studied how responses localize to the tonsil, a major target site for EBV, during primary infection and persistence. In acute IM, EBV-specific effectors were poorly represented among… CONTINUE READING


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