Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

@article{Lelli2009TonotopicGI,
  title={Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.},
  author={Andrea Lelli and Yukako Asai and Andrew Forge and Jeffrey R. Holt and Gw{\'e}na{\"e}lle S. G. G{\'e}l{\'e}oc},
  journal={Journal of neurophysiology},
  year={2009},
  volume={101 6},
  pages={2961-73}
}
Inner ear hair cells are exquisite mechanosensors that transduce nanometer scale deflections of their sensory hair bundles into electrical signals. Several essential elements must be precisely assembled during development to confer the unique structure and function of the mechanotransduction apparatus. Here we investigated the functional development of the transduction complex in outer hair cells along the length of mouse cochlea acutely excised between embryonic day 17 (E17) and postnatal day… CONTINUE READING