Tonicity-dependent regulation of osmoprotective genes in mammalian cells.

  title={Tonicity-dependent regulation of osmoprotective genes in mammalian cells.},
  author={Joan D. Ferraris and Maurice B. Burg},
  journal={Contributions to nephrology},
Cells in the renal medulla are normally exposed to levels of NaCl that are extremely high and that vary with concentration of the urine. Such high levels of NaCl cause cellular perturbations, including increased DNA double-strand breaks, increased oxidation of DNA and proteins, and cytoskeletal alterations. Despite these perturbations the cells are able to survive and function because of osmoprotective responses that include accumulation of compatible organic osmolytes and increased abundance… CONTINUE READING
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