Tonic suppression of gastric acid secretion by endogenous peptides in neonatal rats.

@article{Rao1995TonicSO,
  title={Tonic suppression of gastric acid secretion by endogenous peptides in neonatal rats.},
  author={Radha K Rao and S. Pepperl and F rank Porreca},
  journal={The American journal of physiology},
  year={1995},
  volume={269 5 Pt 1},
  pages={G721-8}
}
Stimulation of gastric acid secretion by secretagogues was measured in developing rats by in vivo and in vitro techniques. Basal acid outputs in vivo were very low in 8- and 14-day-old rats compared with those in 20- and 30-day-old rats. In 20-day-old rats, all secretagogues increased acid output in vivo, whereas only carbachol, pentagastrin, and sulfated cholecystokinin octapeptide (CCK-8S) were active in 14-day-old rats. In contrast, basal acid output in vitro and stimulation by secretagogues… CONTINUE READING
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