Tonic seizures of Lennox-Gastaut syndrome: periictal single-photon emission computed tomography suggests a corticopontine network.

@article{Intusoma2013TonicSO,
  title={Tonic seizures of Lennox-Gastaut syndrome: periictal single-photon emission computed tomography suggests a corticopontine network.},
  author={Utcharee Intusoma and David F. Abbott and Richard A. J. Masterton and Monique R. Stagnitti and Mark R. Newton and Graeme D. Jackson and Jeremy L. Freeman and A. Simon Harvey and John S. Archer},
  journal={Epilepsia},
  year={2013},
  volume={54 12},
  pages={2151-7}
}
PURPOSE Lennox-Gastaut syndrome (LGS) is a severe epileptic disorder with characteristic electroclinical features but diverse etiologies. The shared electroclinical characteristics suggest that common cerebral networks are involved in generating seizures. We sought to reveal these networks by comparing ictal and interictal single-photon emission computed tomography (SPECT). METHODS We identified 10 ictal-interictal SPECT pairs from seven patients with LGS (median age 11 years; range 1-38) who… CONTINUE READING