Tonic inhibitory role of α4β2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice

@article{Rashid2006TonicIR,
  title={Tonic inhibitory role of $\alpha$4$\beta$2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice},
  author={Md Harunor Rashid and Hidemasa Furue and Megumu Yoshimura and Hiroshi Ueda},
  journal={Pain},
  year={2006},
  volume={125},
  pages={125-135}
}
&NA; In the spinal dorsal horn, activation of the nicotinic acetylcholine receptors (nAChR) by exogenously applied agonists is known to enhance inhibitory synaptic transmission, and to produce analgesia. However, it is still unknown whether endogenously released acetylcholine exerts a tonic inhibition on nociceptive transmission through the nAChRs in the spinal dorsal horn. Here, we report the presence of such a tonic inhibitory mechanism in the spinal dorsal horn in mice. In behavioral… Expand
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