Tonic inhibition of chronic pain by neuropeptide Y.

  title={Tonic inhibition of chronic pain by neuropeptide Y.},
  author={Brian Solway and Soma C Bose and Gregory Corder and Renee R. Donahue and Bradley K. Taylor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 17},
Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signals. We found that doxycycline-induced conditional in vivo (Npy(tet/tet)) knockdown of NPY produced rapid, reversible, and repeatable increases in the intensity and duration of tactile and thermal hypersensitivity. Remarkably, when allowed to resolve for several weeks, behavioral hypersensitivity could be… CONTINUE READING
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