Tonic for what ails us? high-affinity GABAA receptors and alcohol.

  title={Tonic for what ails us? high-affinity GABAA receptors and alcohol.},
  author={David M. Lovinger and Gregg E Homanics},
  volume={41 3},
Ethanol interactions with gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, play key roles in acute intoxication. However, the exact mechanisms of these ethanol interactions have been the subject of considerable confusion and controversy. Many studies suggest that ethanol potentiates the function of the type A GABA receptor (GABAA-R). However, these findings have not been consistently replicated in experiments that directly examined the effects of ethanol on… CONTINUE READING

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