Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasis.

@article{Brucker2005TonicAO,
  title={Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasis.},
  author={Peter Brucker and Nicholas J. Izzo and Constance R. Chu},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 10},
  pages={3181-91}
}
OBJECTIVE To determine whether oxygen-dependent activation patterns of hypoxia-inducible factor 1alpha (HIF-1alpha) observed in vascularized tissues are conserved within avascular and hypoxic articular cartilage and whether HIF-1alpha affects cartilage matrix synthesis. METHODS Explants of bovine articular cartilage and primary chondrocytes were exposed… CONTINUE READING