Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus.

@article{Mapelli2009TonicAO,
  title={Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus.},
  author={Lisa Mapelli and Paola Rossi and Thierry Nieus and Egidio D'Angelo},
  journal={Journal of neurophysiology},
  year={2009},
  volume={101 6},
  pages={3089-99}
}
In the cerebellum, granule cells are inhibited by Golgi cells through GABAergic synapses generating complex responses involving both phasic neurotransmitter release and the establishment of ambient gamma-aminobutyric acid (GABA) levels. Although at this synapse the mechanisms of postsynaptic integration have been clarified to a considerable extent, the mechanisms of neurotransmitter release remained largely unknown. Here we have investigated the quantal properties of release during repetitive… CONTINUE READING

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