Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

@article{Kim2017TonabersatPI,
  title={Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels},
  author={Yeri Kim and Jarred M. Griffin and Mohd N. Mat Nor and Jie Zhang and Peter S. Freestone and Helen V. Danesh-Meyer and Ilva D Rupenthal and Monica Acosta and Louise F. B. Nicholson and Simon J. O’Carroll and Colin Richard Green},
  journal={Neurotherapeutics},
  year={2017},
  volume={14},
  pages={1148-1165}
}
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein kinase pathway. We show here that tonabersat directly inhibits connexin43 hemichannel opening. Connexin43 hemichannels have been called “pathological pores” based upon their role in secondary lesion spread, edema, inflammation, and neuronal loss following central nervous system injuries, as well as in chronic inflammatory… CONTINUE READING