Tomoxiprole selectively inhibits cyclooxygenase-2.

@article{West1997TomoxiproleSI,
  title={Tomoxiprole selectively inhibits cyclooxygenase-2.},
  author={Robert Elmer West and Shirley M. Williams and H. D. Nsiama She and Nicholas I. Carruthers and Robert W. Egan and M. Motasilm Billah},
  journal={Prostaglandins},
  year={1997},
  volume={54 6},
  pages={
          891-8
        }
}
Tomoxiprole is a nonsteroidal anti-inflammatory compound that was reported to have low ulcerogenic potential, a quality that would be expected of a cyclooxygenase-2-selective inhibitor, and, in fact, we find it is selective for this isozyme. In stably transfected COS cells, the compound inhibits recombinant human cyclooxygenase-2 (IC50 = 7 nM) more potently than recombinant cyclooxygenase-1 (IC50 = 240 nM), and similar results are obtained with partially pure ovine enzyme preparations. The… CONTINUE READING
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