Tomoxiprole selectively inhibits cyclooxygenase-2.

  title={Tomoxiprole selectively inhibits cyclooxygenase-2.},
  author={Robert Elmer West and Shirley M. Williams and H. D. Nsiama She and Nicholas I. Carruthers and Robert W. Egan and M. Motasilm Billah},
  volume={54 6},
Tomoxiprole is a nonsteroidal anti-inflammatory compound that was reported to have low ulcerogenic potential, a quality that would be expected of a cyclooxygenase-2-selective inhibitor, and, in fact, we find it is selective for this isozyme. In stably transfected COS cells, the compound inhibits recombinant human cyclooxygenase-2 (IC50 = 7 nM) more potently than recombinant cyclooxygenase-1 (IC50 = 240 nM), and similar results are obtained with partially pure ovine enzyme preparations. The… CONTINUE READING