Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans

@article{Gracheva2006TomosynIS,
  title={Tomosyn Inhibits Synaptic Vesicle Priming in 
					Caenorhabditis elegans
				},
  author={Elena O. Gracheva and Anna O. Burdina and A. Miguel Holgado and Martine Berthelot-Grosjean and Brian D Ackley and Gayla Hadwiger and Michael L. Nonet and Robby M. Weimer and Janet E. Richmond},
  journal={PLoS Biology},
  year={2006},
  volume={4},
  pages={191 - 193}
}
Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis of synaptic vesicles in vivo, we analyzed C. elegans tom-1 mutants. Our electrophysiological analysis indicates that evoked postsynaptic responses at tom-1 mutant synapses are prolonged leading to a two-fold increase in total charge transfer. The enhanced response in tom-1… CONTINUE READING

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