Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage.

@article{Otto2004TomorrowsSS,
  title={Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage.},
  author={William R. Otto and Jia Rao},
  journal={Cell proliferation},
  year={2004},
  volume={37 1},
  pages={97-110}
}
Stem cells are regenerating medicine. Advances in stem cell biology, and bone marrow-derived mesenchymal stem cells in particular, are demonstrating that many clinical options once thought to be science fiction may be attainable as fact. The extra- and intra-cellular signalling used by stem cells as they differentiate into lineages appropriate to their destination are becoming understood. Thus, the growth stimuli afforded by LIF, FGF-2 and HGF, as well as the complementary roles of Wnt and… CONTINUE READING