• DOI:10.1053/j.ajkd.2015.12.024
Corpus ID: 25651388

Tolvaptan and Neurocognitive Function in Mild to Moderate Chronic Hyponatremia: A Randomized Trial (INSIGHT).

@article{Verbalis2016TolvaptanAN,
  title={Tolvaptan and Neurocognitive Function in Mild to Moderate Chronic Hyponatremia: A Randomized Trial (INSIGHT).},
  author={J. Verbalis and H. Ellison and M. Hobart and H. Krasa and J. Ouyang and F. Czerwiec},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2016},
  volume={67 6},
  pages={
          893-901
        }
}

J. Verbalis, H. Ellison, +3 authors F. Czerwiec

Published 2016

Medicine

American journal of kidney diseases : the official journal of the National Kidney Foundation

BACKGROUND This trial assessed the effect of tolvaptan on cognition, gait, and postural stability in adult patients with mild to moderate asymptomatic hyponatremia. STUDY DESIGN Phase 3b, multicenter, randomized, double-blind, placebo-controlled, parallel-group pilot study. SETTING & PARTICIPANTS 57 men and women 50 years or older with chronic asymptomatic euvolemic or hypervolemic hyponatremia (serum sodium concentration >120-<135 mEq/L) at 16 sites. INTERVENTION Patients were randomly… CONTINUE READING

View on PubMed

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed