Tolvaptan and Neurocognitive Function in Mild to Moderate Chronic Hyponatremia: A Randomized Trial (INSIGHT).

@article{Verbalis2016TolvaptanAN,
  title={Tolvaptan and Neurocognitive Function in Mild to Moderate Chronic Hyponatremia: A Randomized Trial (INSIGHT).},
  author={J. Verbalis and H. Ellison and M. Hobart and H. Krasa and J. Ouyang and F. Czerwiec},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2016},
  volume={67 6},
  pages={
          893-901
        }
}
  • J. Verbalis, H. Ellison, +3 authors F. Czerwiec
  • Published 2016
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • BACKGROUND This trial assessed the effect of tolvaptan on cognition, gait, and postural stability in adult patients with mild to moderate asymptomatic hyponatremia. STUDY DESIGN Phase 3b, multicenter, randomized, double-blind, placebo-controlled, parallel-group pilot study. SETTING & PARTICIPANTS 57 men and women 50 years or older with chronic asymptomatic euvolemic or hypervolemic hyponatremia (serum sodium concentration >120-<135 mEq/L) at 16 sites. INTERVENTION Patients were randomly… CONTINUE READING
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