Tolvaptan

Abstract

Tolvaptan is an orally administered, nonpeptide, selective arginine vasopressin V1 receptor antagonist that increases free water clearance, thereby correcting low serum sodium levels. SALT-1 and -2, two identical, randomized, double-blind, placebo-controlled, multicentre trials, included patients with hypervolaemic or euvolaemic hyponatraemia (serum sodium… (More)
DOI: 10.2165/11204630-000000000-00000

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