Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.

@article{Zhang2005ToluidineBS,
  title={Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.},
  author={Lewei Zhang and Michele Williams and Catherine F Poh and Denise M Laronde and Joel B. Epstein and Scott Durham and Hisae Nakamura and Ken W. Berean and Allan J Hovan and Nhu D. Le and Gregory Hislop and Robert W Priddy and John Hay and Wan L. Lam and Miriam P Rosin},
  journal={Cancer research},
  year={2005},
  volume={65 17},
  pages={
          8017-21
        }
}
There is a pressing need for the development of visual aids that will facilitate the detection of oral premalignant lesions (OPLs) with a high-risk of progression. Preliminary data suggest that toluidine blue stain may be preferentially retained by OPLs with high-risk molecular clones. In this study, we monitored OPLs from 100 patients without any history of oral cancer for an average of 44 months in order to evaluate the association of toluidine blue status with clinicopathologic risk factors… Expand
Utility of toluidine blue in oral premalignant lesions and squamous cell carcinoma: Continuing research and implications for clinical practice
TLDR
Clinical trials show that TB is useful in identifying asymptomatic OSCC and premalignant lesions at risk of progressing to SCC, which might otherwise be undetected until lesions become more advanced. Expand
Toluidine blue aids in detection of dysplasia and carcinoma in suspicious oral lesions.
TLDR
Clinical examination of leukoplakia, erythroplakia, or erythroleukplakia lesions combined with toluidine blue staining may aid in the identification of severe dysplasia (carcinoma in situ or carcinoma) or carcinomas. Expand
Association of Clinical and Molecular Features of Previously Treated Tumour Sites with Risk for Second Oral Malignancy
TLDR
The results support the need for biopsy of OPLs observed during follow-up, especially when persistent, and suggest that LOH analysis of such biopsies might differentiate those at-risk for SOM, allowing for early intervention. Expand
An actionable test using loss of heterozygosity in identifying high-risk oral premalignant lesions.
TLDR
An objective test using LOH to stratify the risk of LGLs to identify high-risk lesions for oral cancer progression is developed and can be used in the clinical settings to provide clinicians additional information guiding the management of these lesions. Expand
The adjunctive role of toluidine blue in detection of oral premalignant and malignant lesions
TLDR
The findings of this review show that TBlue has utility as an adjunct in the detection of premalignant and malignant oral mucosal lesions and in identifying high-risk areas of lesions for biopsy in patients at increased risk of cancer when evaluated by experienced healthcare workers. Expand
IMPROVING THE DETECTION AND TRIAGE OF ORAL PREMALIGNANT LESIONS IN HIGH-RISK CLINICS AND COMMUNITY DENTAL PRACTICES
TLDR
Data supports the use of TB and FV visualization approaches in high-risk clinics to improve detection of OPLs and produces a framework for transfer of new technology into general dental practice building upon an enhanced triage and referral system. Expand
The need to reassess studies on detection of potentially premalignant and malignant oral lesions.
TLDR
It was observed that the presence of inflammatory changes within the tissue reduced the ability of the pathologists to identify dysplastic or malignant changes and the reliability of histopathology to estimate the risk of progression of a potentially malignant lesion continues to be of concern. Expand
Toluidine Blue Staining in Identification of a Biopsy Site in Potentially Malignant Lesions: A Case–control Study
TLDR
The results seem to be promising, but many such studies have to be done at larger scales to exactly help us in identifying the capability of toluidine blue in the long run. Expand
The usefulness of toluidine staining as a diagnostic tool for precancerous and cancerous oropharyngeal and oral cavity lesions.
TLDR
Toluidine blue stain has been shown to be a reliable aid when clinical examination is unable to differentiate lesions at high risk of progression and then it improves early diagnosis for oral cavity and oropharyngeal cancer. Expand
CLINICOPATHOLOGICAL VALIDATION OF TOLUIDINE BLUE USE, AMONG ORAL PRE-MALIGNANT AND MALIGNANT LESIONS
Aim of the study: Oral squamous cell carcinoma (OSCC) is most commonly develops from pre-existing potential/precursor malignant (PM) lesions. Earliest identication of potential/precursor malignantExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Increased allelic loss in toluidine blue-positive oral premalignant lesions.
TLDR
It is suggested that TB staining may help identify oral premalignant lesions with increased LOH and increased cancer risk, and the study results suggest this stain has been used by clinicians to delineate dysplasia/carcinoma in the oral cavity. Expand
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.
  • M. Rosin, X. Cheng, +8 authors L. Zhang
  • Medicine, Biology
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
TLDR
Analysis of LOH at 3p and 9p could serve as an initial screening for cancer risk of early premalignancies and follow-up investigation for additional losses would be essential for predicting cancer progression. Expand
Allelic losses in OraTest-directed biopsies of patients with prior upper aerodigestive tract malignancy.
TLDR
The data confirm that clonal genetic alterations, especially 9p21 deletion, are often present in the oral epithelia of patients with previous UADT malignancy and, combined with previous studies, suggest that genetic analysis will help stratify patients at risk of developing a secondary oral cancer. Expand
The application of toluidine blue as a diagnostic adjunct in the detection of epithelial dysplasia.
TLDR
For the purpose of quantifying the true sensitivity of toluidine blue, the present study involved the examination of clinically normal mucosa as well as abnormal tissue and compared it with the presence or absence of staining. Expand
Molecular analysis of oral lichen planus. A premalignant lesion?
TLDR
Findings do not support OLP as a lesion at risk for malignant transformation, but such results need to be confirmed by use of other genetic markers as OLP may undergo malignant Transformation through genetic pathways different from those of oral dysplasia. Expand
Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment
TLDR
It is suggested that multiple genetic alterations have already occurred in oral premalignant lesions, allowing at least a focal clonal expansion; and that losses of the 9p21 and 3p14 regions may be related to early processes of tumorigenesis in HNSCC. Expand
Predicting cancer development in oral leukoplakia: ten years of translational research.
  • J. Lee, W. Hong, +12 authors S. Lippman
  • Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
TLDR
The most predictive factors of cancer risk are OPL histology, cancer history, and three of the five biomarkers the authors assessed (chromosomal polysomy, p53 protein expression, and loss of heterozygosity at chromosome 3p or 9p) are the strongest predictors for cancer development. Expand
Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions.
  • T. Axéll, J. Pindborg, C. Smith, I. van der Waal
  • Medicine
  • Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 1996
An international group of epidemiologists, clinicians and pathologists with a special interest in oral white lesions and their precancerous significance has reviewed earlier work on this topic andExpand
Advances in Brief Genetic Progression Model for Head and Neck Cancer : Implications for Field Cancerization 1
TLDR
The local clinical phenomenon of field cancerization seems to involve the expansion and migration of clonally related preneoplastic cells that appear to arise from a sIngle progenitor clone. Expand
Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas.
TLDR
Staining with toluidine blue was demonstrated to be highly reliable in the detection of in situ carcinoma and invasive squamous cell carcinoma, because false-negative results for the lesions did not occur. Expand
...
1
2
3
...