Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies.

@article{Kondo1995TolueneIB,
  title={Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies.},
  author={Hirobumi Kondo and Jian Huang and Gaku Ichihara and Michihiro Kamijima and Ikuo Saito and Eiji Shibata and Yuichiro Ono and Naomi Hisanaga and Yasuhiro Takeuchi and Daiichirou Nakahara},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={51 1},
  pages={97-101}
}
We examined the effects of toluene on the release of dopamine (DA) and its metabolites in rat striatum using microdialysis. Intraperitoneal injection of 800 mg/kg toluene significantly increased motor activity in rats, as did methamphetamine (MAP) (1 mg/kg). However, 800 mg/kg toluene did not affect the extracellular levels of DA, 3,4-dihydroxyphenylacetic acid, homovanillic acid, or 5-hydroxyindoleacetic acid. This is in contrast to MAP, which significantly increased extracellular DA and… CONTINUE READING
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