Toluene increases acute thermonociception in mice.

  title={Toluene increases acute thermonociception in mice.},
  author={Silvia Lorenia Cruz and Nayeli P{\'a}ez-Mart{\'i}nez and Francisco Pellicer and Luis A Salazar and Carolina L{\'o}pez-Rubalcava},
  journal={Behavioural brain research},
  volume={120 2},
Toluene is an abused solvent widely used in several commercial products. Recent evidence indicates that this solvent is a non-competitive inhibitor of NMDA receptors. Since NMDA receptors have been implicated in pain, this paper describes studies of the effects of increasing concentrations of inhaled toluene on nociception. Swiss Webster mice were exposed to toluene (500-8000 ppm) in static exposure chambers for 30 min. After completing the exposure period, animals were tested for nociception… CONTINUE READING