Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs

  title={Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs},
  author={S. Cruz and P. Soberanes-Ch{\'a}vez and N. P{\'a}ez-Mart{\'i}nez and C. L{\'o}pez-Rubalcava},
  • S. Cruz, P. Soberanes-Chávez, +1 author C. López-Rubalcava
  • Published 2009
  • Chemistry, Medicine
  • Psychopharmacology
  • RationaleMany abused solvents share a profile of effects with classical antidepressants. For example, toluene, which is a representative and widely abused solvent, has been reported to increase both serotonin and noradrenaline levels in several brain areas after an acute exposure and to act as a noncompetitive antagonist of the glutamatergic N-methyl-d-aspartic acid (NMDA) receptor subtype. Therefore, it is possible that toluene could possess antidepressant-like actions.ObjectiveTo provide an… CONTINUE READING
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