Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs

@article{Cruz2009TolueneHA,
  title={Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs},
  author={Silvia L. Cruz and Paulina Soberanes-Ch{\'a}vez and Nayeli P{\'a}ez-Mart{\'i}nez and Carolina L{\'o}pez-Rubalcava},
  journal={Psychopharmacology},
  year={2009},
  volume={204},
  pages={279-286}
}
RationaleMany abused solvents share a profile of effects with classical antidepressants. For example, toluene, which is a representative and widely abused solvent, has been reported to increase both serotonin and noradrenaline levels in several brain areas after an acute exposure and to act as a noncompetitive antagonist of the glutamatergic N-methyl-d-aspartic acid (NMDA) receptor subtype. Therefore, it is possible that toluene could possess antidepressant-like actions.ObjectiveTo provide an… 
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