Toluene diisocyanate-induced in vitro tracheal hyperreactivity in the mouse.

@article{Scheerens1996TolueneDI,
  title={Toluene diisocyanate-induced in vitro tracheal hyperreactivity in the mouse.},
  author={Heleen Scheerens and Theresa L. Buckley and E M Davidse and Johan Garssen and Frans P. Nijkamp and Henk van Loveren},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={154 4 Pt 1},
  pages={858-65}
}
Toluene diisocyantate (TDI) is a low-molecular-weight compound that is known to cause occupational asthma in 5% to 10% of exposed workers. These patients exhibit marked airway hyperresponsiveness and granulocyte accumulation in the airways, and 10% to 20% were also determined to have TDI-specific IgE in their serum. In this study, we developed a murine model for TDI-induced asthma. After several sensitization and challenge regimens were tested, it was decided that optimal sensitization was… CONTINUE READING
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