Tolrestat in the primary prevention of diabetic neuropathy.

@article{Giugliano1995TolrestatIT,
  title={Tolrestat in the primary prevention of diabetic neuropathy.},
  author={Dario Giugliano and Rosa Acampora and Raffaele Marfella and G di Maro and Nicla de Rosa and Lucio Misso and Antonio Ceriello and Antonio Quatraro and F D'onofrio},
  journal={Diabetes care},
  year={1995},
  volume={18 4},
  pages={536-41}
}
OBJECTIVE To compare the effects of tolrestat and placebo in patients with subclinical diabetic neuropathy. RESEARCH DESIGN AND METHODS Non-insulin-dependent diabetes mellitus (NIDDM) patients with early involvement of the autonomic nervous system were identified by only one pathological (outside the 99% confidence interval of the normal population) squatting test (vagal or sympathetic). Fifty-seven patients entered a randomized, placebo-controlled, double-blind, parallel 52-week study of… CONTINUE READING