Tolmetin Sodium, a New Anti‐Arthritis Drug: Double‐Blind and Long‐Term Studies

  title={Tolmetin Sodium, a New Anti‐Arthritis Drug: Double‐Blind and Long‐Term Studies},
  author={L J Cordrey},
  journal={Journal of the American Geriatrics Society},
  • L. Cordrey
  • Published 1 October 1976
  • Medicine
  • Journal of the American Geriatrics Society
ABSTRACT: The effectiveness of tolmetin sodium in the treatment of rheumatoid arthritis was evaluated by: 1) a 12‐week, double‐blind study with a dosage range of 800–1600 mg daily; and 2) an open 2‐year study with a dosage range of 400–2400 mg daily. The double‐blind study involved 14 patients (7 tolmetin sodium, 7 placebo), and the long‐term study involved 24 patients. At frequent intervals, evaluations were made of joint pain, swelling, stiffness and inflammation; grip strength; walking time… 
Long‐Term Efficacy and Safety of Tolmetin Sodium in Treatment of Geriatric Patients with Rheumatoid Arthritis and Osteoarthritis: A Retrospective Study
  • W. O'Brien
  • Medicine
    Journal of clinical pharmacology
  • 1983
Tolmetin, which is an antiinflammatory agent with a short half‐life, can provide adequate, safe therapy in the geriatric population and fails to reveal any unusual or serious conditions which would contraindicate its use in the elderly patient.
Clinical Use of Tolmetin Sodium in Patients with Ankylosing Spondylitis: A Review
  • A. Calin
  • Medicine
    Journal of clinical pharmacology
  • 1983
Objective and subjective assessments showed that both tolmetin sodium and indomethacin provided significant therapeutic benefits to patients with AS and the two drugs showed similar adverse reaction profiles.
Meta-analysis of dyspepsia and nonsteroidal antiinflammatory drugs.
Clinical trial data indicate that high dosages of any NSAID along with any dosage of indomethacin, meclofenamate, or piroxicam increase the risk of dyspepsia by about 3-fold.
A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs.
These data support an association between the use of NSAID and serious upper GI complications, including estimates from different study designs, which must be viewed with caution.
Do NSAIDs cause dyspepsia? a meta-analysis evaluating alternative dyspepsia definitions
Using the strict definition, based solely on epigastric pain-related symptoms, NSAIDs increased the risk of dyspepsia by 36% (p < 0.05) and these findings may be useful in creating a standardized definition of NSAID-related dyspePSia.
Crystal structure of the non-steroidal anti-inflammatory drug (NSAID) tolmetin sodium
The asymmetric unit of the title two-dimensional polymer, sodium 2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetate dihydrate, contains two sodium cations, two organic anions and two water molecules.
Может ли амтолметил гуацил пригодиться в хирургической практике
Although amtolmetin guaci is mainly used for the relief of pain in diseases of joints and spine (osteoarthritis, back pain, rheumatoid arthritis, etc.), it can be used for pain management in surgical patients.
Sports activities and their effects on high density lipoprotein cholesterol and coronary heart disease.
  • K. Francis
  • Medicine
    The Journal of orthopaedic and sports physical therapy
  • 1979
Evidence is accumulating that indicates that blood cholesterol is associated with increased risk of developing heart disease, and the relationship between physical activity and blood cholesterol has not been definitely established, though preliminary reports indicated that exercise may provide some protective effect to coronary heart disease.
N-Pyrrylarylsulfones with High Therapeutic Potential
The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-tetracyclic, tricyclic and non-cyclic compounds.


Results of a One‐Year Trial of Tolmetin in Patients with Rheumatoid Arthritis
It is indicated that tolmetin affords symptomatic relief of rheumatoid arthritis and its use results in global improvement in 80 per cent of the patients, and a net improvement in one or more of the parameters used to assess disease activity.
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.
Tolmetin and McN-2891 appear to offer potential safety and efficacy in the treatment of both rheumatoid arthritis and osteoarthritis as reflected by the wide separation between the anti-inflammatory and ulcerogenic dose-response curves and large anti- inflammatory indices.
Indomethacin--its rightful place in treatment.
  • C. Smyth
  • Medicine
    Annals of internal medicine
  • 1970
Abstract Indomethacin has been in clinical use for 7 years and has aroused more interest, controversy, and discussion than any other antirheumatic agent since the corticoids. Good to excellent resu...
Tolmetin versus placebo for the treatment of rheumatoid arthritis: a sequential double-blind clinical trial.
The effects of Tolectin in rheumatoid arthritis. (Presented at the 13th International Congress of Rheumatology, Kyoto, Japan, 1973
  • Excerpta Medica Foundation, International Congress Series No
  • 1973
Pharmacologic evaluation of TolectinB (tolmetin, McN-2559) and McN2891, two anti-inflammatory agents
  • J Pharmacol Exp Therap
  • 1973
Salicylate therapy for rheumatoid arthritis, in Arthritis and Allied Conditions, ed
  • Lea and Febiger,
  • 1972
Evaluation of the endocrine system response to tolmetin in patients with acute flares of rheumatoid arthritis
  • Tolmetin: A New Non-steroid Anti-inflammatory Agent (Proceedings of a Symposium
Tolmetin versus aspirin in the treatment of rheumatoid arthritis: a controlled double-blind study (Abstract Proc. 6th Pan-American Congress on Rheumatic Diseases, Toronto)
  • J Rheumatol
  • 1974