Tolmetin Sodium, a New Anti‐Arthritis Drug: Double‐Blind and Long‐Term Studies

@article{Cordrey1976TolmetinSA,
  title={Tolmetin Sodium, a New Anti‐Arthritis Drug: Double‐Blind and Long‐Term Studies},
  author={L J Cordrey},
  journal={Journal of the American Geriatrics Society},
  year={1976},
  volume={24}
}
  • L. Cordrey
  • Published 1 October 1976
  • Medicine
  • Journal of the American Geriatrics Society
ABSTRACT: The effectiveness of tolmetin sodium in the treatment of rheumatoid arthritis was evaluated by: 1) a 12‐week, double‐blind study with a dosage range of 800–1600 mg daily; and 2) an open 2‐year study with a dosage range of 400–2400 mg daily. The double‐blind study involved 14 patients (7 tolmetin sodium, 7 placebo), and the long‐term study involved 24 patients. At frequent intervals, evaluations were made of joint pain, swelling, stiffness and inflammation; grip strength; walking time… 
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References

SHOWING 1-10 OF 10 REFERENCES
Results of a One‐Year Trial of Tolmetin in Patients with Rheumatoid Arthritis
TLDR
It is indicated that tolmetin affords symptomatic relief of rheumatoid arthritis and its use results in global improvement in 80 per cent of the patients, and a net improvement in one or more of the parameters used to assess disease activity.
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.
TLDR
Tolmetin and McN-2891 appear to offer potential safety and efficacy in the treatment of both rheumatoid arthritis and osteoarthritis as reflected by the wide separation between the anti-inflammatory and ulcerogenic dose-response curves and large anti- inflammatory indices.
Indomethacin--its rightful place in treatment.
  • C. Smyth
  • Medicine
    Annals of internal medicine
  • 1970
Abstract Indomethacin has been in clinical use for 7 years and has aroused more interest, controversy, and discussion than any other antirheumatic agent since the corticoids. Good to excellent resu...
Tolmetin versus placebo for the treatment of rheumatoid arthritis: a sequential double-blind clinical trial.
The effects of Tolectin in rheumatoid arthritis. (Presented at the 13th International Congress of Rheumatology, Kyoto, Japan, 1973
  • Excerpta Medica Foundation, International Congress Series No
  • 1973
Pharmacologic evaluation of TolectinB (tolmetin, McN-2559) and McN2891, two anti-inflammatory agents
  • J Pharmacol Exp Therap
  • 1973
Salicylate therapy for rheumatoid arthritis, in Arthritis and Allied Conditions, ed
  • Lea and Febiger,
  • 1972
Evaluation of the endocrine system response to tolmetin in patients with acute flares of rheumatoid arthritis
  • Tolmetin: A New Non-steroid Anti-inflammatory Agent (Proceedings of a Symposium
Tolmetin versus aspirin in the treatment of rheumatoid arthritis: a controlled double-blind study (Abstract Proc. 6th Pan-American Congress on Rheumatic Diseases, Toronto)
  • J Rheumatol
  • 1974