Tolmetin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Rheumatic Diseases

@article{Brogden2012TolmetinAR,
  title={Tolmetin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Rheumatic Diseases},
  author={Rex N. Brogden and Rennie C. Heel and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={15},
  pages={429-450}
}
SummarySynopsis: Synopsis: Tolmetin1 (1-methyl-5-p-toluoylpyrrole-2-acetic acid) is a new non-steroidal anti-inflammatory, antipyretic and analgesic agent advocated for use in rheumatoid arthritis, juvenile rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis.Published data suggest that in rheumatoid arthritis, tolmetin 1200 to 1600mg daily is comparable in effectiveness with about one-eighth its dose of indomethacin and with moderate to high doses of aspirin (4 to 4.5g… 

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