Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

  title={Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor},
  author={K. Burns and J. Clatworthy and L. Martin and F. Martinon and C. Plumpton and B. Maschera and A. Lewis and Keith Ray and J. Tschopp and F. Volpe},
  journal={Nature Cell Biology},
  • K. Burns, J. Clatworthy, +7 authors F. Volpe
  • Published 2000
  • Chemistry, Medicine
  • Nature Cell Biology
  • Interleukin-1 (IL-1) is a proinflammatory cytokine that elicits its pleiotropic effects through activation of the transcription factors NF-κB and AP-1. Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1β treatment, Tollip is present… CONTINUE READING
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