Toll-like receptors regulation of viral infection and disease.

@article{Thompson2008TolllikeRR,
  title={Toll-like receptors regulation of viral infection and disease.},
  author={J. Michael Thompson and Akiko Iwasaki},
  journal={Advanced drug delivery reviews},
  year={2008},
  volume={60 7},
  pages={
          786-94
        }
}
In recent years, it has become increasingly evident that mammalian Toll-like receptors (TLRs) play a critical role in determining the outcome of virus infection. TLRs have evolved to recognize viral nucleic acids, and promote the stimulation of innate and adaptive immune responses. Interestingly, the study of mice harboring deficiencies in various TLR proteins and their adaptors suggests that TLR activation promotes protective anti-viral immunity in some cases, while exacerbating virus-induced… CONTINUE READING

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