Toll-like receptors regulate B cell cytokine production in patients with diabetes

@article{Jagannathan2010TolllikeRR,
  title={Toll-like receptors regulate B cell cytokine production in patients with diabetes},
  author={M. Jagannathan and M. Mcdonnell and Y. Liang and H. Hasturk and J. Hetzel and D. Rubin and A. Kantarci and T. E. Dyke and L. Ganley-Leal and B. Nikolajczyk},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={1461-1471}
}
Aims/hypothesisUnderstanding cellular and molecular events in diabetes mellitus will identify new approaches for therapy. Immune system cells are important modulators of chronic inflammation in diabetes mellitus, but the role of B cells is not adequately studied. The aim of this work was to define the function of B cells in diabetes mellitus patients through focus on B cell responses to pattern recognition receptors.MethodsWe measured expression and function of Toll-like receptors (TLRs) on… Expand
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