Toll-like receptors in the induction of the innate immune response

@article{Aderem2000TolllikeRI,
  title={Toll-like receptors in the induction of the innate immune response},
  author={Alan Aderem and Richard J Ulevitch},
  journal={Nature},
  year={2000},
  volume={406},
  pages={782-787}
}
The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights… 

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...

References

SHOWING 1-10 OF 58 REFERENCES

Phylogenetic perspectives in innate immunity.

TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

Signaling mechanisms in the antimicrobial host defense of Drosophila.

Toll signaling pathways in the innate immune response.

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.

TLDR
It is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs), and that Activation of TLRs by microbes may initiate innate defense mechanisms against infectious pathogens.

Lipid A diversity and the innate host response to bacterial infection.

  • R. Darveau
  • Biology
    Current opinion in microbiology
  • 1998

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

TLDR
It is shown that Toll-like receptor 2 is recruited specifically to macrophage phagosomes containing yeast, and that a point mutation in the receptor abrogates inflammatory responses to yeast and Gram-positive bacteria, but not to Gram-negative bacteria.

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

TLDR
It is shown that Toll-like receptor 2 (TLR2) is a signalling receptor that is activated by LPS in a response that depends on LPS-binding protein and is enhanced by CD14, and that TLR2 is a direct mediator of signalling by L PS.

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.

TLDR
A loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products.

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1

TLDR
It is reported here that macrophages of C3H/HeJ mice, carrying a mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60, and this is the first report of a putative endogenous ligand of the Tlr4 complex.

Mechanisms of phagocytosis in macrophages.

TLDR
Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
...