Toll-like receptors in ocular surface diseases: overview and new findings.

@article{Lambiase2011TolllikeRI,
  title={Toll-like receptors in ocular surface diseases: overview and new findings.},
  author={Alessandro Lambiase and Alessandra Micera and Marta Sacchetti and Flavio Mantelli and Stefano Bonini},
  journal={Clinical science},
  year={2011},
  volume={120 10},
  pages={
          441-50
        }
}
The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence mechanisms. TLRs (Toll-like receptors), widely expressed by the ocular surface, are able to recognize microbial pathogens and to trigger the earliest immune response leading to inflammation. Increasing evidence highlights the crucial role of TLRs in regulating innate immune responses during ocular… 
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