Toll-like receptors in bony fish: from genomics to function.

  title={Toll-like receptors in bony fish: from genomics to function.},
  author={Yniv Palti},
  journal={Developmental and comparative immunology},
  volume={35 12},
Receptors that recognize conserved pathogen molecules are the first line of cellular innate immunity defense. Toll-like receptors (TLRs) are the best understood of the innate immune receptors that detect infections in mammals. Key features of the fish TLRs and the factors involved in their signaling cascade have high structural similarity to the mammalian TLR system. However, the fish TLRs also exhibit very distinct features and large diversity which is likely derived from their diverse… CONTINUE READING


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