Toll-like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis.

Abstract

Mammalian TLRs in adult animals serve indispensable functions in establishing innate and adaptive immunity and contributing to the homeostasis of surrounding tissues. However, the expression and function of TLRs during mammalian embryonic development has not been studied so far. Here, we show that CD45(+) CD11b(+) F4/80(+) macrophages from 10.5-day embryo… (More)
DOI: 10.1002/eji.201344040

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