Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter.

@article{Albrecht2004TolllikeRD,
  title={Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter.},
  author={Inka Albrecht and Thomas Tapmeier and Stefan Zimmermann and Markus Frey and Klaus M Heeg and Alexander H Dalpke},
  journal={EMBO reports},
  year={2004},
  volume={5 2},
  pages={172-7}
}
Toll-like receptors (TLRs) mediate recognition of microbial components. Despite activation of a shared set of signal transduction molecules, the biological effects of certain TLR agonists differ considerably. In macrophages and dendritic cells, stimulation by the prototypical stimuli CpG-DNA (TLR9), lipopolysaccharide (LPS; TLR4) and lipoteichoic acid (LTA; TLR2) resulted in striking differences in expression of IL-12. However, these stimuli induced similar amounts of the common proinflammatory… CONTINUE READING

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