Toll-like receptors as therapeutic targets in gastrointestinal diseases.

@article{PimentelNunes2010TolllikeRA,
  title={Toll-like receptors as therapeutic targets in gastrointestinal diseases.},
  author={Pedro Pimentel-Nunes and Jo{\~a}o Bruno Soares and Roberto Roncon-Albuquerque and M{\'a}rio Dinis-Ribeiro and Adelino F Leite-Moreira},
  journal={Expert opinion on therapeutic targets},
  year={2010},
  volume={14 4},
  pages={347-68}
}
IMPORTANCE OF THE FIELD Toll-like receptors (TLRs) are innate immunity receptors that recognize several different antigens, initiating immunological/inflammatory responses. Recent evidence associates numerous pathophysiological processes and diseases with dysregulated activation of these receptors, conferring a potential therapeutic value to their modulation. AREAS COVERED IN THIS REVIEW The aim of this systematic review that covers literature from the past 10 years is to address the role of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis.

International journal of clinical and experimental pathology • 2014
View 1 Excerpt

Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver • 2013

References

Publications referenced by this paper.
Showing 1-10 of 288 references

Pimentel-Nunes, Soares, Roncon-Albuquerque Jr, Dinis-Ribeiro & Leite-Moreira Expert Opin

AG Testro, PJ Gow, +3 authors 4 on mononuclear cells in patients with advanced cir 2009
Ther. Targets • 2010
View 20 Excerpts
Highly Influenced

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

The Journal of clinical investigation • 2009
View 8 Excerpts
Highly Influenced

Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis.

American journal of physiology. Gastrointestinal and liver physiology • 2007
View 20 Excerpts
Highly Influenced

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.

American journal of physiology. Gastrointestinal and liver physiology • 2006
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…