Toll-like receptors as molecular switches

  title={Toll-like receptors as molecular switches},
  author={Nicholas J Gay and Monique Gangloff and Alexander N. R. Weber},
  journal={Nature Reviews Immunology},
Members of the Toll family of single-pass transmembrane receptors are key mediators of innate immunity in both vertebrates and invertebrates. They respond to various pathogen-associated stimuli and transduce the complex signalling responses that are required for inflammation and for the subsequent development of adaptive immunity. Here, we propose a molecular mechanism for signalling by the Toll and Toll-like receptors that involves a series of protein conformational changes initiated by… CONTINUE READING