Toll-like receptors and their role in the development of autoimmune diseases.

@article{Toubi2004TolllikeRA,
  title={Toll-like receptors and their role in the development of autoimmune diseases.},
  author={Elias Elias Toubi and Yehuda Shoenfeld},
  journal={Autoimmunity},
  year={2004},
  volume={37 3},
  pages={183-8}
}
Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling pathways may unravel molecular mechanisms of self-tolerance and the means underlying the development of autoimmunity. The maturation of antigen-presenting cells (APCs), in… CONTINUE READING

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