Toll-like receptors and diabetes.

  title={Toll-like receptors and diabetes.},
  author={Florence S Wong and Li Wen},
  journal={Annals of the New York Academy of Sciences},
Toll-like receptors (TLRs) recognize molecular patterns relating to a variety of microbial infections. Stimulation through TLRs leads to activation of antigen-presenting cells, production of inflammatory cytokines creating inflammation, and production of type 1 interferons (IFNs) that include IFN-alpha and -beta, and exerts direct effects on regulatory cells. These effects can direct the immune response, dealing with the immediate problems of infection and activating more specific responses of… CONTINUE READING
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Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes

  • Kim, S H.
  • Immunity
  • 2007

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

  • J Tian
  • Nat. Immunol
  • 2007

Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

  • A Zanin-Zhorov
  • J. Clin. Invest
  • 2006

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