Toll-like receptors and diabetes.

@article{Wong2008TolllikeRA,
  title={Toll-like receptors and diabetes.},
  author={Florence S Wong and Li Wen},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1150},
  pages={123-32}
}
Toll-like receptors (TLRs) recognize molecular patterns relating to a variety of microbial infections. Stimulation through TLRs leads to activation of antigen-presenting cells, production of inflammatory cytokines creating inflammation, and production of type 1 interferons (IFNs) that include IFN-alpha and -beta, and exerts direct effects on regulatory cells. These effects can direct the immune response, dealing with the immediate problems of infection and activating more specific responses of… CONTINUE READING
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