Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.

@article{Tabeta2004TolllikeR9,
  title={Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.},
  author={Koichi Tabeta and Philippe T Georgel and Edith M. Janssen and Xin Du and Kasper Hoebe and Karine Crozat and Suzanne Mudd and Louis Shamel and Sosathya Sovath and Jason Goode and Lena Alexopoulou and Richard A. Flavell and Bruce Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 10},
  pages={
          3516-21
        }
}
  • K. Tabeta, P. Georgel, +10 authors B. Beutler
  • Published 2004
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen. Type I IFN production can be induced both by unmethylated CpG-oligodeoxynucleotide and by double-stranded RNA. Here, we describe a codominant CpG-ODN unresponsive phenotype that results from an N-ethyl-N-nitrosourea-induced missense mutation in the Tlr9 gene (Tlr9(CpG1)). Mice homozygous for the Tlr9… Expand
1. Toll-like receptor (TLR) と抗ウィルス応答
TLDR
The relationship between the TLR 3-TICAM-1 pathway and viral infection is reviewed and it is shown that the IFN-beta induction in mDCs appears in part due to the function of TICam-1. Expand
The TLR3/TICAM-1 Pathway Is Mandatory for Innate Immune Responses to Poliovirus Infection
TLDR
Evidence is presented that the TLR3/TICAM-1 pathway functions are dominant in host protection and innate immune responses against PV infection, and this study uses human PVR transgenic mice as well as IPS-1−/− and TIC AM-1 mice to find that TICAM -1 is essential for antiviral responses that suppress PV infection. Expand
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
TLDR
Evidence is provided for a critical role of a Toll-like receptor 3 (TLR3)-dependent type II IFN signaling pathway in antiviral innate immune response against Coxsackievirus group B serotype 3 (CVB3), a member of the positive-stranded RNA virus family picornaviridae and most prevalent virus associated with chronic dilated cardiomyopathy. Expand
Toll-like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E.
TLDR
The early HCMV-triggered immune response of human moDCs appears to be independent of TLR3 signaling, as shown by microarray analysis and quantitative real-time PCR. Expand
Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner
TLDR
Results suggest that a novel signaling pathway(s) other than TLR- and IPS-1-dependent pathways participates in the production of type I IFN in response to AcNPV infection. Expand
Antiviral responses induced by the TLR3 pathway
TLDR
The current knowledge on the role of TLR3 during viral infection, and the current understanding of theTLR3‐signalling cascade that operates via the adaptor protein TICAM‐1 are reviewed. Expand
Toll-Like Receptor 3 Signaling on Macrophages Is Required for Survival Following Coxsackievirus B4 Infection
TLDR
It is demonstrated that TLR3 plays an essential role in recognizing the molecular signatures associated with specific viruses including CB4, and that the MyD88-dependent signaling pathways are not only unable to compensate for the loss ofTLR3, they are also dispensable in the response to this RNA virus. Expand
Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus
TLDR
It is concluded that, in mice, in the authors' experimental settings, MyD88 is redundant for IFN-I responses and overall defense against a systemic herpes virus infection, contrary to the current dogma but consistent with the situation in humans. Expand
Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection1
TLDR
It is shown that TLR7 and TLR9 exert redundant functions for IFN-α/β, IL-12p40, and TNF-α production by pDCs in vivo during MCMV infection, the first demonstration of the implication ofTLR7 in the recognition of a DNA virus. Expand
Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection
TLDR
It is shown here that an absence of TLR3 enhances WNV mortality in mice and increases viral burden in the brain, and data suggest thatTLR3 serves a protective role against WNV in part, by restricting replication in neurons. Expand
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