Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line.

@article{Udan2008TolllikeR2,
  title={Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line.},
  author={Maria L D Udan and Deepa Ajit and Nikkilina R Crouse and Michael R Nichols},
  journal={Journal of neurochemistry},
  year={2008},
  volume={104 2},
  pages={524-33}
}
The primary molecules for mediating the innate immune response are the Toll-like family of receptors (TLRs). Recent work has established that amyloid-beta (Abeta) fibrils, the primary components of senile plaques in Alzheimer's disease (AD), can interact with the TLR2/4 accessory protein CD14. Using antibody neutralization assays and tumor necrosis factor alpha release in the human monocytic THP-1 cell line, we determined that both TLR2 and TLR4 mediated an inflammatory response to aggregated… CONTINUE READING