Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury

  title={Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury},
  author={Krisztina Szilvia Rusai and Daniel Sollinger and Marcus Baumann and Bettina Wagner and Matthias Strobl and Christoph Schmaderer and Marcel Roos and Carsten J Kirschning and Uwe W Heemann and Jens Lutz},
  journal={Pediatric Nephrology},
Toll-like receptors (TLRs) are an evolutionarily conserved family of cell membrane receptors that are part of the innate immunity system playing an important role as a first response to tissue injury. TLR2 and TLR4 are constitutively expressed on renal epithelium, and their expression is enhanced following renal ischemia/reperfusion (I/R) injury. Genetic deletion of either TLR2 or TLR4 protects from renal I/R injury. However, it is not known whether deletion of both combined protects the kidney… CONTINUE READING


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