Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values.

@article{Brea2011TolllikeR2,
  title={Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values.},
  author={David Brea and M Victoria Blanco and Pedro Ramos-Cabrer and Octavio Moldes and Sabrina Delgado Arias and Mar{\'i}a P{\'e}rez-Mato and Rogelio Leira and Tom{\'a}s Sobrino and J. Vx00E1zquez Castillo},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 6},
  pages={
          1424-31
        }
}
Stroke triggers an intense inflammatory response that could be a consequence of Toll-like receptors (TLRs) activation. However, the clinical significance and the therapeutic possibilities of TLR in stroke is not completely clear. In this study, we analyze the association between the expression of TLR2 and TLR4, inflammatory molecules and endogenous ligands, and clinical outcome of ischemic stroke patients, and we test the potential of TLR2/TLR4 and their endogenous ligands as therapeutic… CONTINUE READING
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