Toll-like receptors: their role in allergy and non-allergic inflammatory disease.

  title={Toll-like receptors: their role in allergy and non-allergic inflammatory disease.},
  author={Ian Sabroe and Lisa C. Parker and Anthony Gerard Wilson and Moira K B Whyte and Steven K. Dower},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={32 7},
The human TLRs comprise an important and interesting group of receptors that regulate pathogen-related responses, and play as yet uncharacterized roles in the amplication of sterile inflammation. Signalling through these receptors, which are powerfully coupled in gene transcription processes, has powerful immunostimulatory and immunomodulatory effects. Exploitation of TLR signalling will probably lead to novel effective therapies for allergic disease, in the first instance through more… CONTINUE READING
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