Toll-like receptors, wound healing, and carcinogenesis

@article{Kluwe2008TolllikeRW,
  title={Toll-like receptors, wound healing, and carcinogenesis},
  author={Johannes Kluwe and Ali Andre Mencin and Robert F. Schwabe},
  journal={Journal of Molecular Medicine},
  year={2008},
  volume={87},
  pages={125-138}
}
Following acute injury, the concerted action of resident and nonresident cell populations evokes wound healing responses that entail a temporary increase in inflammation, extracellular matrix production, and proliferation to ultimately restore normal organ architecture. However, chronic injury evokes a perpetuating wound healing response promoting the development of fibrosis, organ failure, and cancer. Recent evidence points toward toll-like receptors (TLRs) as important regulators of… CONTINUE READING

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